Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility

E Vargas; S Petrou; CA Reid

Journal article

Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility

E Vargas, S Petrou, CA Reid

Journal of Physiology | WILEY-BLACKWELL | Published : 2013

DOI: 10.1113/jphysiol.2012.234674

Abstract

The expression of Na+-K+-2Cl- cotransporter (NKCC1) is responsible for high intracellular Cl- resulting in the excitatory action of GABAA receptor activation in the developing brain. Giant depolarizing potentials (GDPs) are spontaneous network oscillations that involve GABAA receptors and are thought to be important in establishing neuronal circuit wiring. Earlier work established that seizure susceptibility in the GABAAγ2R43Q epilepsy mouse is impacted by developmental consequences of impaired GABAA receptor function. We investigated the potential mechanism of the developmental influence by recording GDPs in the CA3 pyramidal neurons from brain slices of the neonatal GABAAγ2R43Q mouse. Inte..

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University of Melbourne Researchers

Christopher Reid Author

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Grants

Awarded by NHMRC

Awarded by ARC

Awarded by Australian Research Council

Funding Acknowledgements

This study was supported by NHMRC project grant 628520 to C. A. R., and a NHMRC program grant 400121 to S. P. C. A. R. also acknowledges the support of an ARC Future Fellowship (FT0990628). SP is a NHMRC Senior Research Fellow. The authors have no financial conflict to declare with regards to this research.